Study of Utilization of Antiplatelet Agents in Coronary Heart Disease Patients in Private Hospital in Surabaya

Ike Dhiah Rochmawati, Zakiah Rizka Rachmadania Arifin

Abstract


ABSTRACT

 

Antiplatelet is the most commonly drug used as secondary prevention for Coronary Heart Disease (CHD). The aim of this study was to determine the profile of the use of antiplatelet related with its efficacy and side effects. Observational methods with cross sectional approach for 3 months follow up was used,  a descriptive analysis carried out at the private hospital in Surabaya.  Results from this study: aspirin 80 mg was the most prescribed antiplatelet in patients with the incidence of ischemic events 9%. Higher ischemic events also seen in patients with hypertension, dyslipidemia, and Diabetes Mellitus. Bleeding and gastrointestinal disturbance as side effects occurred in 4 patients who used aspirin as antiplatelet, and based for Naranjo scale can be concluded as possible adverse drug reaction.

 

Keywords: Coronary Heart Disease, Antiplatelet , Ischemic events, Bleeding

 


Full Text:

PDF

References


Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI, 2018, Riset Kesehatan Dasar, Kementrian Kesehatan RI

Departemen Kesehatan RI, 2017, Penyakit Jantung Penyebab Kematian Tertinggi, Kemenkes Ingatkan Cerdik, Kementrian Kesehatan Republik Indonesia,1-2

Gregg D, J Pascal, Clermont G, 2003, Platelets and Cardiovascular Disease. American Heart Assoiciation Inc. 1-2

Hankey GJ, Eikelboom W, 2003, Antiplatelet Drugs. The Medical Journal of Australia. 178(11): 568

Hwang IC, Jeon JY, Kim Y, Kim HM,et al, 2015, Association between Aspirin Therapy and Clinical Outcomes in Patienys with Non-Obstructive Coronary Artery Disease:A Cohort Study.Plos One. 1-15

Ibanez B, James S, Agewall S, et al, 2017, ESC Guidelines for the management of acute myocardial infraction in patients presenting with ST-segment elevation. European Heart Journal. 30.

Ittaman SV., VanWormer JJ., Rezkalla SH., 2014. The Role of Aspirin in the Prevention of Cardiovascular Disease.Clin Med Res. 12(3-4): 147-154

Knuuti J, Wijns W, Saraste A, Capodanno D, Barbato E, Funck-Brentano C, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal (2019)00, 1-71

Listiyana AD, Mardiana, Prameswari GN, 2013, Obesitas Sentral dan Kadar Kolesterol Darah Total. Jurnal Kesehatan Masyrakat. 9(1): 38-39

Nelwan EJ, Widjajanto E, Andarini S, et al¸2016, Modified Risk Factors for Coronary Heart Disease (CHD) in Minahasa Ethnic Group From Manado City Indonesia. J.Exp.Life. 6(2): 91

Nicholaos Kakouros, Jeffrey J. Rade,Antonios Kourliouros, and Jon R. Resar, Platelet Function in Patients with DiabetesMellitus: From a Theoretical to a Practical Perspective. International Journal of Endocrinology.Volume 2011:1-14. doi:10.1155/2011/742719

Montalescot G, Sechtem U, Achenbach S, et al, 2013, Guidelines On The Management of Stable Coronary Artery Disease. European Heart Journal. 34 (38): 2949–3003

Pilgrim T, Windecker S, 2014, Antiplatelet therapy for secondary prevention of coronary artery disease. Heart. 100 (22): 1,3

Rodriguez G, Perez M, Hennekens CH, et al¸2016, Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies. Plos One. 11(8): 9,14

Roffi M., Patrono C., Collet J., 2015, Guidelines For The Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation.European Heart Journal. 286

Tayeb HM, Nelson AJ, Willoughby SR, 2011, Antiplatelet therapy in acute coronary syndromes: current agents and impact on patient outcomes. Patient Relat Outcome Meas. 2: 7-19

Vanhees L, Rauch B, Piepoli M, et al, 2012. Importance of Characteristic and Modalities of Physical Activity and Exercise in the Management of Cardiovascular Health in Individuals with Cardiovascular Disease (Part III).European Journal of Preventive Cardiology. 19(6):1333-56.

WHO, 2011, Global Atlas on Cardiovascular disease prevention and control. Geneva: WHO

Yasuda H., Matsuo Y., Sato Y., et al, 2015, Treatment and Prevention of Gastrointestinal Bleeding in Patients Receiving Antiplatelet Therapy, World Journal of Critical Care Medicine, 4 (1): 40-46, (online), (diakses 04-01-2018) https://www.wjgnet.com/2220-3141/full/v4/i1/40.htm

Weber T, Lang I, Zweiker R, et al 2016, Hypertension and Coronary Artery Disease: epidemiology, physiology, effects of treatment and recommendations.Wien Klin Wochenschr. 128(13-14):467




DOI: http://dx.doi.org/10.20527/jps.v7i1.8079

Article Metrics

Abstract view : 35 times
PDF - 25 times

Refbacks

  • There are currently no refbacks.


Jurnal Pharmascience Published BY:

Program Studi Farmasi Universitas Lambung Mangkurat

Jurnal Pharmascience is indexed by:


 

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.