HUBUNGAN DERAJAT DIFERENSIASI DENGAN JUMLAH SEL RADANG LIMFOSIT PADA HISTOPATOLOGI KANKER KOLOREKTAL

Dina Wahyuni, Agung Ary Wibowo, Ika Kustiyah Oktaviyanti, Winardi Budiwinata, Lena Rosida

Abstract


Colorectal cancer is the third most common cause of death in the world. Colorectal cancer was ranked third in Indonesia. Colorectal cancer patients had a statistically significant difference in lymphocyte inflammatory cell values compared to healthy controls. Colorectal cancer patients had much higher lymphocyte inflammatory cell values than healthy controls. Lymphocyte infiltration can provide additional prognostic information for treatment options in some situations. Histopathology is an essential factor in determining the diagnosis, treatment management, and prognosis. Histopathological examination of the degree of differentiation can determine whether a neoplasm is malignant. The prognosis of colorectal cancer depends on the presence or absence of metastases and the degree of differentiation; with a histopathological examination, we can see the spread of inflammatory cell infiltration at the degree of differentiation which can be used to determine the prognosis of colorectal cancer. The normality test results of the p-value of inflammatory lymphocyte cells were <0.001. Correlation data analysis using the rank-spearman test showed p>0.05 in colorectal cancer patients at Ulin Hospital Banjarmasin.

 


Keywords


colorectal cancer, degree of differentiation, lymphocyte cells

Full Text:

PDF

References


Suksmarini NMPW, Dewi NNA, Sumadi IWJ. Metilasi DNA dalam perkembangan kanker kolorektal. Intisari Sains Medis. 2018;124–30.

Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer Journal For Clinicians. 2021;71(3):209–49.

Rompis AY, Nyoman AD. Aspek genetik kanker kolorektal. Jurnal Sains dan Kesehatan. 2020;2(3):236–45.

Widhyasih RM, Rahmadhanti SD, Fajrunni'mah R. Carcinoembryonic antigen (CEA) dan neutrofil-to-limfosit ratio (NLR) sebagai faktor prediktif kanker kolorektal. Jurnal Ilmu dan Teknologi Kesehatan. 2019;7(1):68–6.

Rahdi DR, Wibowo AA, Rosida L. Gambaran faktor risiko pasien kanker kolorektal di RSUD Ulin Banjarmasin periode April-September 2014. Berkala Kedokteran. 2015;11(2):221–32.

Auclin E, Zaanan A, Vernerey D, et al. Subgroups and prognostication in stage iii colon cancer: future perspectives for adjuvant therapy. Ann Oncol. 2017;28(5):958–68.

Dworakowska D, Grossman AB. Colonic cancer and acromegaly. Front Endocrinol Lausanne. 2019;(10):1–9.

Engstrom PF, Arnoletti JP, Benson AB, et al. NCCN clinical practice guidelines in oncology colon cancer. National Comprehensive Cancer Network. 2012;7(8):778–831.

Zhou X, Shang J, Liu X, et al. Clinical significance and oncogenic activity of grwd1 overexpression in the development of colon cancer. Onco Targets Ther. 2021;(14):1565–80.

Muhajir, Hanifah A, Ismet MN, Fajar AY. Gambaran karakteristik penderita kanker kolorektal di bagian patologi anatomi RSAI Bandung periode 2012- 2016. Prosiding Pendidikan Dokter: 2017. p. 61–71.

Recio BA, Cagir B. Colon cancer. In StatPearls [Internet]. 2022 [cited 2022 May 14]. Available from: https://www.ncbi.nlm.nih.gov/books/N BK470380/

To'Bungan N, A'liyah SH, Wijayanti N, Fachiroh J. Epidemiologi, stadium, dan derajat diferensiasi kanker kepala dan leher. Biogenesis: Jurnal Ilmiah Biologi. 2015;3(1):47–52.

Balatif R, Lubis NDA, Yuni I. Obesitas dengan kanker kolorektal, bagaimana keterkaitan keduanya?. Scientific Medical Journal.2021; 2(2):116-122.

Marzouq O, John S, Alex T. Review of histopathological and molecular prognostic features in colorectal cancer. Cancers. 2011;3(2):2767-2810.

Nikijuluw, Akyuwen G, Taihuttu YMJ. Hubungan antara faktor usia, jenis kelamin, dan obesitas dengan kejadian kanker kolorektal di RSUD Dr M. Haulussy Ambon periode 2013-2015. Molucca Medica.2018;11(1):61-69.

Arania R, Ade UD. Hubungan antara usia dan jenis kelamin dengan kejadian kanker kolorektal di RSUD dr. H. Abdul Moeloek Bandar Lampung tahun 2012- 2014. Jurnal Ilmu Kedokteran dan Kesehatan.2015;3(2):1-13.

Lin JH, Zhang SM, Rexrode KM, et al. Association between sex hormones and colorectal cancer risk in men and women.Clinical Gastroenterology and Hepatology.2013;11(4):419-424.

Zheng DC, Zheng C, Wu J, et al. Neutrophil-lymphocyte ratio predicts the prognosis of patients with colorectal cancer: a meta-analysis. Int J Clin Exp Med.2016;9(1):78-90.

Eid S, Hasan H, Aleem DA, et al. The impact of neutrophil to lymphocytic ratio (NLR) as a predictor of treatment outcomes in rectal cancers: a retrospective cohort study.Journal of Cancer Therapy.2019;10(9):755-777.

Bai Z, Zhou Y, Ye Z, et al. Tumor- infiltrating lymphocytes in colorectal cancer: the fundamental indication and application on immunotherapy. Frontiers in Immunology.2021;12:1-14.

Devianti L, Salmiah A.Hubungan antara beberapa faktor prognostik klinikopatologik kanker kolorektal di RSUD Dr. Achmad Mochtar Bukittinggi tahun 2015-2017.Jurnal Kesehatan Andalas.2019;8(2):269-274.

Xiao H, Yoon YS, Hong SM, et al. Poorly differentiated colorectal cancers correlation of microsatellite instability with clinicopathologic features and survival. American Journal of Clinical Pathology.2013;140(3):341-347.

Yamauchi H, Sakurai S, Tsukagoshi R, et al.A case of very well-differentiated adenocancerwith carcinoid tumor in the ascending colon. International Surgery.2014;99(2):132-136.

Bonetti LR, Barresi V, Bettelli S, et al. Poorly differentiated clusters (PDC) in colorectal cancer what is and ought to be known.Diagnostic Pathology.2016;11(1): 1-4.

Yolanda SC, Murti IS, Sawitri E.The association of age, gender, and carcinoembryonic antigen (CEA) levels with adenocancer grading in patients with colorectal cancer. Jurnal Medika Karya Ilmiah Kesehatan. 2022;7(1): 55- 61.

Rozek LS, Schmit SL, Greenson JK, et al. Tumor-infiltrating lymphocytes, crohn’s-like lymphoid reaction, and survival from colorectal cancer. Journal of the National Cancer Institute.2016;108(8):1-8.

Novitasari, Mulyadi K, Indrayani LPI. Hubungan derajat diferensiasi dan tingkat kedalaman invasi tumor terhadap densitas sel limfosit t cd3 dan limfosit b cd20 pada kanker kolorektal. Majalah Patologi.2017;26(2):48-55.

Mojarad EN, Mohammadpuor S, Esafahani AT, et al. Intratumoral infiltrating lymphocytes correlate with improved survival in colorectal cancer patients: Independent of oncogenetic features.Journal of Cellular Physiology. 2019;234(4): 4768-4777.

Sakti A, Sulastri H, Auline S. Hubungan kepadatan limfosit t sitotoksik cd8 dengan karakteristik klinikopatologi kanker kolorektal. Sriwijaya Journal of




DOI: https://doi.org/10.20527/ht.v6i3.11450

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Homeostasis

Creative Commons License
Homeostasis is licensed under a Creative Commons Attribution 4.0 International License

Program Studi Kedokteran Program Sarjana
Fakultas Kedokteran Universitas Lambung Mangkurat
Jalan Veteran No.128 Banjarmasin
email : [email protected]