DERAJAT INFILTRASI LIMFOSIT PADA PENDERITA KANKER KOLOREKTAL SUB-TIPE ADENOKARSINOMA
Abstract
Cancer is the second leading cause of death which contributes 13% of deaths from a total of 22% of deaths from non-communicable diseases in the world. One contributor to the number of cancer deaths in the world is colorectal cancer. The prognosis of colorectal cancer depend on the stage of cancer at time of diagnosis. However, the prognosis of colorectal cancer can also be determined by looking at the degree of infiltration of lymphocytes in cancer. The purpose of this research is to find out the degree of lymphocytes infiltration in patients with colorectal cancer in Laboratory of Anatomical Pathology Banjarmasin from January to December 2013. The method uses descriptive research by observing the colorectal cancer tissues were obtained from the Laboratory of Pathology Banjarmasin. From a study of 32 samples, found the degree of mild lymphocytic infiltration occurred in 12 patients (37.5%), moderate lymphocytic infiltration occurred in 12 patients (37.5%), and severe lymphocyte infiltration occurred in 8 patients (25%). From this study, found that there are differences in the degree of infiltration of lymphocytes in patients with colorectal cancer.
Keywords: Colorectal Cancer, Lymphocyte Infiltration, Prognosis
Full Text:
PDFReferences
Oemiati, Ratih, Ekowati R, Antonius YK. Prevalensi tumor dan beberapa faktor yang mempengaruhinya di Indonesia. Buletin Penelitian Kesehatan. 2011; 4: 190-204.
Departemen Kesehatan RI. laporan nasional hasil riset kesehatan dasar tahun 2007. Jakarta: Badan Litbang DepKes RI. 2008
Haggar FA, Robin PB. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clinic In Colon And Rectal Surgery. 2009; 22: 191-197
Siegel R, Carol DS, Ahmedin J. Colorectal cancer statistics 2014. CA Cancer J Clin. 2014; 64: 104-117
Winarto EP, July I, Sri NJS. Prevalensi kanker kolorektal di rumah sakit Immanuel Bandung Periode Januari 2005 – Desember 2007. JKM. 2009; 8: 138-143.
American Cancer Society. Colorectal cancer facts & figures 2011-2013. Atlanta: American Cancer Society. 2011
Graham J, Andrew C, Angela B, et al. Colorectal cancer: the diagnosis and management of colorectal cancer. NICE. 2011 : 1-186
Zhivotovskiy AS, Anton GK, Artur ZA. Colorectal cancer risk factor among the population of south-east Siberia: a case-control study. Asian Pasific Journal of Cancer Prevention. 2012; 13: 5183-5188.
Ratnasari D. Perbedaan derajat diferensiasi adenokarsinoma kolorektal pada gologan usia muda, baya, dan tua di RSUP Dr. Kariadi Semarang. (skripsi S1). Program Pendidikan Sarjana FK Universitas Diponegoro.2012
Galon J, Anne C, Fatima SC, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006; 313: 1960-1963.
Ohtani H. Focus on TILs : Prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer. Cancer Immunity. 2007; 7: 1-9
Koch M, Phillip B, Daniel A, et al. Tumor infiltrating T lymphocytes in colorectal cancer: tumor selective activation and cytotoxic activity in situ. Annals of Surgery. 2006; 244: 986-993.
Majek O, Adam G, Lina J, et al. Sex differences in colorectal cancer survival : population-based analysis of 164,996 colorectal cancer patients in Germany. PLoS ONE. 2013; 8(7): 1-7
Leon MP, Marino M, Benatti P, et al. Trend of incidence, subsite distribution and staging of colorectal neoplasm in the 15-year experience of a specialized cancer registry. Annals of Oncology. 2004; 15: 940-946
Kresno SB. Imunologi: diagnosis dan prosedur laboratorium. Jakarta: Badan Penerbit FKUI.2010
Swann JB, Mark JS. Immune surveillance of tumour. The Journal of Clinical Investigation. 2007; 117(5): 1137-1146
Dunn GP, Lloyd JO, Robert DS. The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 2004; 21: 137-148
Rahir G, Muriel M. Tumor microenvironment and lymphocyte infiltration. Cancer Immunol Immunother. 2012; 61: 751-759
DOI: http://dx.doi.org/10.20527/jbk.v11i2.141
Article Metrics
Abstract view : 990 timesPDF - 4876 times
Refbacks
- There are currently no refbacks.
Copyright (c) 2016 Jurnal Berkala Kedokteran
Indexed by :

This work is licensed under a Creative Commons Attribution 4.0 International License.





