Perbandingan Efektifitas Asetol-Klopidogrel Terhadap Pasien Penderita Stroke Iskemik Akut

Sari Dianita Purnama, Pagan Pambudi, Nelly Al Audhah

Abstract


ABSTRACT: Acute ischemic stroke can make patients get neurology problems that show the signs of paralyze in some part of body and  suddenly decrease awareness. The prevalence of acute ischemic stroke which  high enough and the bad effects cause the preventing of acute ischemic stroke with right medicine becomes important. Acetosal works as an anti-thromboxane which often known as aspiryn. Clopidogrel is kind of thienophiridyn class drugs that works as an anti-platelet for acute ischemic stroke therapy so that can avoid blood cloting happened. This research aims to know if they have different effectivity or not to acute ischemic stroke therapy by acetosal and combine of acetosal-clopidogrel together. The method uses analythic observational with cohort. The research begins by counting the stroke scale use NIHSS (National Institute of Health Stroke Scale) at the first come to hospital, before patient cured by any drugs, and then repeat the NIHSS’s scoring at seventh day after therapy. Research did for four months with sample that gathered 32 people. First, did normality test to data and after the normality have been proven, use unpaired T-test with interval of confidence 95% that shows the result, there’s no significant difference between acetosal and combined acetosal-clopidogrel for acute ischemic stroke.

 

Keywords: acetosal, clopidogrel, acute ischemic stroke, NIHSS

 

ABSTRAK: Stroke iskemik akut dapat mengakibatkan defisit neurologi yang sebagian besar akan menimbulkan gejala kelumpuhan pada bagian tertentu dan atau terjadi penurunan kesadaran secara mendadak. Angka kejadian yang cukup tinggi dan efeknya terhadap penderita membuat pencegahan stroke iskemik akut dengan obat yang tepat sangat diperlukan. Asetosal adalah terapi yang bekerja sebagai antitromboksan yang sering pula dikenal dengan nama aspirin. Klopidogrel merupakan obat oral kelas tienopiridin yang berperan sebagai antiplatelet dalam terapi stroke iskemik akut sehingga mencegah terjadinya gumpalan darah.  Penelitian ini bertujuan untuk mengetahui apakah terdapat  perbedaan efektivitas pada terapi stroke iskemik akut menggunakan asetosal dan kombinasi asetosal-klopidogrel. Metode yang digunakan bersifat observasional analitik dengan pendekatan cohort. Penelitian dilakukan dengan cara menghitung derajat stroke pasien menggunakan NIHSS (National Institute of Health Stroke Scale) ketika hari pertama dirawat di rumah sakit sebelum mendapat terapi dan hari ketujuh setelah dilakukan terapi. Penelitian dilakukan selama empat bulan dengan jumlah sampel sebanyak 32 orang. Data pertama-tama diuji normalitas distribusinya kemudian setelah terbukti distribusi normal maka dilakukan uji T tidak berpasangan dengan tingkat kepercayaan sebesar 95% yang menunjukan bahwa tidak terdapat perbedaan bermakna pada terapi stroke iskemik akut dengan asetosal dan kombinasi asetosal klopidogrel.

 

Kata-kata kunci: asetosal, klopidogrel, stroke iskemik akut, NIHSS


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DOI: http://dx.doi.org/10.20527/jbk.v9i2.941

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