Pengaruh moderate intensity continuous exercise terhadap kadar irisin serum pada wanita remaja obesitas

Ido Nur Abdulloh; Sugiharto Sugiharto; Purwo Sri Rejeki

doi:10.20527/multilateral.v20i1.10069

Pengaruh moderate intensity continuous exercise terhadap kadar irisin serum pada wanita remaja obesitas

Ido Nur Abdulloh, Sugiharto Sugiharto, Purwo Sri Rejeki

Abstract

Tujuan penelitian ini untuk menganalisis pengaruh latihan dengan intensitas sedang yakni Moderate Intensity Continuous Exercise (MICE) terhadap peningkatan kadar irisin serum. Metode penelitian menggunakan true experimental-randomized pretest-posttest control group design dengan partisipasi 20 subjek wanita dengan Indeks Massa Tubuh (IMT) 25-35 kg/m². Subjek secara random dibagi menjadi 2 kelompok, yakni CONT (n= 10, kontrol tanpa intervensi), dan MICE (n= 10, Moderate Intensity Continuous Exercise). Intervensi dilakukan secara continuous selama 30 menit. Intervensi dilakukan pukul 08.00-10.00 a.m. Pengambilan darah dilakukan pre-exercise dan 15 menit post-exercise. Pengukuran kadar irisin menggunakan metode ELISA. Teknik analisis data menggunakan t-test dan Analysis of Variance (ANOVA) dengan SPSS. Hasil penelitian menunjukkan terdapat peningkatan irisin serum pre dan post-test secara signifikan pada MICE (4,31±0,49 to 5,57±0,71) (p<0,05). Sementara pada CONT tidak terjadi perbedaan yang signifikan (4,35±0,69 to 4,39±0,64) (p>0,05). Berdasarkan hasil penelitian dapat disimpulkan bahwa MICE dapat meningkatkan kadar irisin serum pada wanita remaja obesitas saat setelah latihan fisik sehingga dapat dijadikan salah satu langkah terapi nonfarmakologis dalam menghambat permasalahan obesitas.

Keywords

latihan fisik; obesitas; weight loss; anti-obesity-agents

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References

Arief, N. A., Kuntjoro, B. F. T. and Suroto, S. (2020). Gambaran Aktifitas Fisik Dan Perilaku Pasif Mahasiswa Pendidikan Olahraga Selama Pandemi Covid-19. Multilateral Jurnal Pendidikan Jasmani dan Olahraga, 19(2), p. 175. doi: https://doi.org/10.20527/multilateral.v19i2.9564

Bociek, A. (2019). Irisin - evidence for benefits resulting from physical activity. European Journal of Biological Research, 9(3), pp. 165–172. doi: https://doi.org/10.5281/zenodo.3385065

Bostrom, P. et al. (2012). A PGC1- a -dependent myokine that drives brown-fat-like development of white fat and thermogenesis. NATURE, 481(1), pp. 463–468. doi: https://doi.org/10.1038/nature10777

Bull, F. C. et al. (2020). World Health Organization 2020 guidelines on physical activity and sedentary behaviour. British Journal of Sports Medicine, 54(24), pp. 1451–1462. doi: https://doi.org/10.1136/bjsports-2020-102955

Canto, C. et al. (2009) ‘AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity’, Nature, 458(7241), pp. 1056–1060. doi: https://doi.org/10.1038/nature07813.AMPK

Centers of disease control and prevention (2011). Body mass index: Considerations for practitioners. CDC, p. 4. Available at: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Body+Mass+Index+:+Considerations+for+Practitioners#3%5Cnhttp://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Body+mass+index:+Considerations+for+practitioners#3.

Di Cesare, M. et al. (2016). Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants. The Lancet. NCD Risk Factor Collaboration. Open Access article distributed under the terms of CC BY, 387(10026), pp. 1377–1396. doi: https://doi.org/10.1016/S0140-6736(16)30054-X

Chia, K. S. W. et al. (2017). The benefit of exercise training in pulmonary hypertension: a clinical review. Internal Medicine Journal, 47(4), pp. 361–369. doi: https://doi.org/10.1111/imj.13159

Choi, Y. K. et al. (2013). Serum irisin levels in new-onset type 2 diabetes. Diabetes Research and Clinical Practice. Elsevier Ireland Ltd, 100(1), pp. 96–101. doi: https://doi.org/10.1016/j.diabres.2013.01.007

Coral, A. R. et al. (2008). Accuracy of body mass index in diagnosing obesity in the adult general population. International Journal of Obesity, 1(32), pp. 959–966. doi: https://doi.org/10.1038/ijo.2008.11

Daskalopoulou, S. S. et al. (2014). Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. European Journal of Endocrinology, 171(3), pp. 343–352. doi: https://doi.org/10.1530/EJE-14-0204

Du, X. L., Jiang, W. X. and Lv, Z. T. (2016). Lower Circulating Irisin Level in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis. Hormone and Metabolic Research, 48(10), pp. 644–652. doi: https://doi.org/10.1055/s-0042-108730

Fernandez-Marcos, P. J. and Auwerx, J. (2011). Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. American Journal of Clinical Nutrition, 93(4), pp. 884–890. doi: https://doi.org/10.3945/ajcn.110.001917

Fulco, M. et al. (2008). Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt. Dev cell, 14(5), pp. 1–22. doi: https://doi.org/10.1161/CIRCULATIONAHA.110.956839

He, M. et al. (2001). Body fat determination by dual energy X-ray absorptiometry and its relation to body mass index and waist circumference in Hong Kong Chinese. International Journal of Obesity, 1(25), pp. 748–752.

Hejazi, K. et al. (2019). Report of Health Care The Effect of Physical Activity on Adipose Tissue and Skeletal Muscles : A Literature Review. 5(1), pp. 54–62.

Herrera, C. A. et al. (2017). Muscle irisin response to aerobic vs HIIT in overweight female adolescents. Diabetology & Metabolic Syndrome. BioMed Central, pp. 5–11. doi: https://doi.org/10.1186/s13098-017-0302-5

Huh et al. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism. Elsevier B.V., 61(12), pp. 1725–1738. doi: https://doi.org/10.1016/j.metabol.2012.09.002

Jackson, A. S. et al. (2002). The effect of sex, age and race on estimating percentage body fat from body mass index: The Heritage Family Study. International Journal of Obesity, 26(6), pp. 789–796. doi: https://doi.org/10.1038/sj.ijo.0802006

Kamaruddin, I. (2020). Penurunan Kadar Gula Darah Penderita Diabetes Melalui Aktivitas Fisik Senam Bugar Lansia. Multilateral Jurnal Pendidikan Jasmani dan Olahraga, 19(2), p. 128. doi: https://doi.org/10.20527/multilateral.v19i2.8883

Kraemer, R.R., Shockett, P., Webb, N.D., Shah, U. and Castracane, V. D. (2014). A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Hormone and Metabolic Research, 46(2), pp. 150–154. doi: https://doi.org/10.1055/s-0033-1355381

Lee, P., Linderman, Joyce D., et al. (2014). Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metabolism. Elsevier Inc., 19(2), pp. 302–309. doi: https://doi.org/10.1016/j.cmet.2013.12.017

Löffler, D. et al. (2015). Serum irisin levels are regulated by acute strenuous exercise. Journal of Clinical Endocrinology and Metabolism, 100(4), pp. 1289–1299. doi: https://doi.org/10.1210/jc.2014-2932

Luiz, I. et al. (2017). Combined training , FNDC5 / irisin levels and metabolic markers in obese men : A randomised controlled trial. 1391(March). doi: https://doi.org/10.1080/17461391.2017.1296025

Mannerkorpi, K., Landin-Wilhelmsen, K., Larsson, A., Cider, Å., Arodell, O., & Bjersing, J. L. (2017). Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia. BMC musculoskeletal disorders, 18(1), 1-8.

Mazur-bialy, A. I. and Poche, E. (2017). Anti-Inflammatory Properties of Irisin , Mediator of Physical Activity, Are Connected with TLR4 / MyD88 Signaling Pathway Activation. International Journal of Molecular Sciences Article, 18(701), pp. 1–11. doi: https://doi.org/10.3390/ijms18040701

Mihaylova, M. M. and Shaw, R. J. (2012). The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism. Nature Cell biology, 13(9), pp. 1016–1023. doi: https://doi.org/10.1038/ncb2329

Mulhim, M. (2020). Perbandingan Pengaruh Pelatihan Senam Jantung Sehat Seri Ii Dan Senam Kesegaran Jasmani 2000 Terhadap Kebugaran Jasmani. Jurnal Multilateral, 13(2), pp. 165–184. doi: https://doi.org/10.20527/multilateral.v13i2.2490

Norheim, F. et al. (2014). The effects of acute and chronic exercise on PGC-1 a, irisin and browning of subcutaneous adipose tissue in humans. FEBS journal, 281(2014), pp. 739–749. doi: 10.1111/febs.12619.

Nuttall, F. Q. (2015). Body mass index: Obesity, BMI, and health: A critical review. Nutrition Today, 50(3), pp. 117–128. doi: https://doi.org/10.1097/NT.0000000000000092

Paley, C. A. and Johnson, M. I. (2018). Abdominal obesity and metabolic syndrome: Exercise as medicine?. BMC Sports Science, Medicine and Rehabilitation. BMC Sports Science, Medicine and Rehabilitation, 10(1), pp. 1–8. doi: https://doi.org/10.1186/s13102-018-0097-1

Pasco, J. A. et al. (2014). Body mass index and measures of body fat for defining obesity and underweight: A cross-sectional, population-based study. BMC Obesity, 1(1), pp. 1–7. doi: https://doi.org/10.1186/2052-9538-1-9

Pedersen, B. K. and Febbraio, M. A. (2012). Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology. Nature Publishing Group, 8(8), pp. 457–465. doi: https://doi.org/10.1038/nrendo.2012.49

Pedersen, B. K. and Saltin, B. (2006). Evidence for prescribing exercise as therapy in chronic disease. Scandinavian Journal of Medicine and Science in Sports, 16(SUPPL. 1), pp. 3–63. doi: https://doi.org/10.1111/j.1600-0838.2006.00520.x

Perakakis, N. et al. (2017). Physiology and role of irisin in glucose homeostasis. Nature Reviews Endocrinology. Nature Publishing Group, 13(6), pp. 324–337. doi: https://doi.org/10.1038/nrendo.2016.221

Simbolon, M. E. M. and Firdausi, D. K. A. (2018). Asosiasi Antara Indeks Massa Tubuh, Kebugaran Tubuh Bagian Atas Dan Daya Tahan Respirasi Di Kalangan Remaja. Journal Physical Education, Health and Recreation, 2(2), p. 118. doi: https://doi.org/10.24114/pjkr.v2i2.9555

Soori, R. et al. (2016). The Effect of Submaximal Aerobic Training on Serum Irisin Level in Obese Men; with Emphasis on the Role of Irisin in Insulin-Resistance Change. Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 19(4), pp. 20–30.

Sudikno, S. et al. (2015). Faktor Risiko Overweight dan Obese pada Orang Dewasa di Indonesia (Analisis Data Riset Kesehatan Dasar 2013 (Analisis Data Riset Kesehatan Dasar 2013). Gizi Indonesia, 38(2), p. 91. doi: https://doi.org/10.36457/gizindo.v38i2.183

Tsuchiya, Y. et al. (2014). High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. The Tohoku journal of experimental medicine, 233(2), pp. 135–40. doi: https://doi.org/10.1620/tjem.233.135.Correspondence

Tsuchiya, Y., Mizuno, S. and Goto, K. (2018). Irisin response to downhill running exercise in humans. Journal of Exercise Nutrition & Biochemistry, 22(2), pp. 12–17. doi: https://doi.org/10.20463/jenb.2018.0011

Ulven, S. M. et al. (2015). An acute bout of exercise modulate the inflammatory response in peripheral blood mononuclear cells in healthy young men. Archives Of Physiology And Biochemistry. Informa UK Ltd, pp. 1–9. doi: https://doi.org/10.3109/13813455.2014.1003566

Wadley, A. J. et al. (2015). Low volume – high intensity interval exercise elicits antioxidant and anti-inflammatory effects in humans. Journal of Sports Sciences, 1(April 2015), pp. 37–41. doi: https://doi.org/10.1080/02640414.2015.1035666

Wang, G. et al. (2019). Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Article Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. molecullar cell. Elsevier Inc., 74(1), pp. 1–14. doi: https://doi.org/10.1016/j.molcel.2019.03.021

WHO (2019). World Health Statitics Overview 2019 Monitoring Health for the SDGs.

Winn, N. C. et al. (2017). Plasma irisin modestly increases during moderate and high-intensity afternoon exercise in obese females. PLoS ONE, 12(1), pp. 1–12. doi: https://doi.org/10.1371/journal.pone.0170690

Wrann, C. D. et al. (2013). Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metabolism, 18(5), pp. 617–632. doi: https://doi.org/10.1016/j.cmet.2013.09.008.Exercise

Zhang, N. and Ma, G. (2018). WHO Guideline: Assessing and Managing Children at Primary Health-care Facilities to Prevent overweight and Obesity in the Context of the Double Burden of Malnutrition, Global Health Journal. doi: https://doi.org/10.1016/s2414-6447(19)30136-8

Zhang, T. et al. (2017). Long-term Impact of Temporal Sequence from Childhood Obesity to Hyperinsulinemia on Adult Metabolic Syndrome and Diabetes: The Bogalusa Heart Study. Scientific Reports. Nature Publishing Group, 7(February), pp. 1–7. doi: https://doi.org/10.1038/srep43422

DOI: http://dx.doi.org/10.20527/multilateral.v20i1.10069