Review: Pengembangan Sistem Penghantaran Berbasis NLC (Nanostructur Lipid Carier) sebagai Skin Anti-Aging

Ahmad Bagus Mindiarto; Garnadi Jafar; Al-fira Putriyanti

doi:10.20527/jps.v11i2.20136

Review: Pengembangan Sistem Penghantaran Berbasis NLC (Nanostructur Lipid Carier) sebagai Skin Anti-Aging

Ahmad Bagus Mindiarto, Garnadi Jafar, Al-fira Putriyanti

Abstract

Indonesia memiliki iklim tropis dengan suhu rata-rata 25°C hingga 30°C dan dua musim utama, yaitu hujan dan kemarau. Keindahan dan kesehatan kulit sangat penting bagi masyarakat Indonesia, yang baru-baru ini diakui dalam peringkat kecantikan global. Penuaan kulit, yang ditandai dengan penurunan produksi kolagen dan elastisitas, serta munculnya keriput, dipengaruhi oleh faktor eksternal seperti sinar matahari dan polusi. Anti-aging mengacu pada metode dan produk untuk memperlambat tanda-tanda penuaan. Pengembangan sistem penghantaran berbasis NLC (Nanostructured Lipid Carrier) adalah pendekatan terbaru dalam meningkatkan efektivitas produk anti-aging, dengan partikel lipid nano yang mampu menembus lapisan kulit lebih dalam. Tujuan penelitian ini adalah membandingkan kinerja NLC dengan berbagai sistem penghantaran sehingga dapat diketahui sejauh mana NLC lebih unggul dalam menjaga stabilitas dan meningkatkan penetrasi bahan aktif anti-aging. Metode yang digunakan yaitu Artikel ilmiah dikumpulkan dari sumber nasional dan internasional 10 tahun terakhir (2014-2024). Hasil penelitian menunjukkan bahwa NLC meningkatkan penetrasi bahan aktif ke lapisan kulit yang lebih dalam, memperbaiki hidrasi kulit, dan mengurangi tanda-tanda penuaan. Kesimpulannya, sistem penghantaran berbasis NLC menawarkan pendekatan efektif dalam terapi anti-aging dan memiliki potensi besar untuk aplikasi dalam produk kosmetik dan perawatan kulit.

Keywords

Anti aging, Penuaan kulit, Penetrasi obat, Sistem penghantaran, Nanopartikel

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DOI: http://dx.doi.org/10.20527/jps.v11i2.20136