Profil dan Evaluasi Terapi Anemia pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisa di BLUD RS Ratu Zalecha Martapura Periode Juli-Oktober 2014
Abstract
Abstrak
Gagal Ginjal Kronik (GGK) merupakan suatu penyakit yang dapat menyebabkan terjadinya anemia karena ketidakmampuan ginjal memproduksi eritropoetin. Penelitian ini bertujuan untuk melihat profil terapi anemia serta mengevaluasi terapi anemia pasien GGK yang menjalani hemodialisa di BLUD RS Ratu Zalecha Martapura. Metode penelitian ini bersifat prospektif yang dilakukan selama bulan Juli-Oktober 2014. Berdasarkan hasil penelitian dapat disimpulkan bahwa dari 215 data pemeriksaan laboratorium pasien GGK terdapat 99,1 % kejadian anemia dan hanya 65,1 % saja yang mendapatkan terapi anemia. Terapi anemia yang diberikan yaitu untuk terapi tunggal seperti eritropoietin sebesar 8,5 %; vitamin B kompleks sebesar 21,8 %; vitamin B1 sebesar 1,5%; dan transfusi darah sebesar 11,2 %; untuk terapi kombinasi 2 obat yang diberikan yaitu vitamin B kompleks dengan eritropoeitin α sebesar 52,9 %; vitamin B kompleks dengan vitamin B1 sebesar 2,7 %; Vitamin B kompleks dengan transfusi darah sebesar 0,6 %; sedangkan untuk terapi 3 kombinasinya yaitu vitamin B kompleks, eritropoietin dan transfusi darah sebesar 0,9 %; Evaluasi terapi anemia pada pasien GGK yang menjalani hemodialisa belum sesuai dengan pedoman terapi yaitu pemeriksaan laboratorium yang kurang lengkap seperti jumlah retikolosit absolut, serum transferin saturation (TSAT), serta serum vitamin B12 serta asam folat, selain itu masih terdapat pemberian terapi anemia yang tidak mempertimbangkan kondisi pasien.
Kata Kunci : Terapi Anemia, GGK, Hemodialisa
Abstract
A Chronic Kidney Disease (CKD) is a disease that can lead to anemia because of the inability of the kidney to produce erythropoietin. This study aimed to observe the pattern of anemia therapy and to evaluate the therapy anemia of Chronic Kidney Disease patients conducting hemodialysis at Ratu Zalecha Hospital Martapura. This study was conducted prospectively from July to October 2014. Based on the results it could be concluded that from 215 patients’ laboratory check-up data there were 99.1% prevalence of anemia and of those only 65.1% got anemia therapy. The applied anemia therapies for singular therapy were erythropoietin at the amount of 8,5 %; vitamin B complex at the amount of 21.8 %; vitamin B1 at the amount of 1.5 % and blood transfusion at the amount of 11.2 %; for the combined therapies the applied 2 medicines were iron with erythropoietin at the amount of 52.9 %; vitamin B complex with vitamin B1 at the amount of 2.7%; vitamin B complex with blood transfusion at the amount of 0.6%; whereas the 3 combination therapy was vitamin B complex, erythropoietin and blood transfusion at the amount of 0.9 %. The evaluation of anemia therapy Chronic Kidney Disease patients conducting hemodialysis was not completely appropriate as instructed in therapy manual such less comprehensive laboratorium check-up such us absolute reticoloycte, serum transferin saturation (TSAT), serum vitamin B12 and folate acid, aside from that many treatments which not considered with the patients’ condition.
Keywords : Therapy Anemia, CKD, Hemodialysis
Keywords
Full Text:
PDFReferences
Aslam. 2003. Farmasi Klinik (Clinical Pharmacy). PT. Elex Media Koputindo, Jakarta.
Beaird S.L. 2000. HMG-CoA Reductase Inhibitors: Assessing Differences in Drug Interaction and Safety Profils. Journal of the American Pharmacists Association.
Bjelaković G., I. Stojanović, G. B. Bjelaković, D. Pavlović, G. Kocić, & A.D. Milić. 2002. Competitive Inhibitors of Enzymes and Their Therapeutic Application. Medicine and Biology. 9: 201 – 206.
Chi H., S. Wang, J. Chen, & J. Zhang. 2007. Long-term effects of simvastatin on protection against atrial fibrillation in patients with acute myocardial infarction. Journal of Geriatric Cardiology. 4: 144-147.
Cohen L.H., R.E Van Leeuwen RE., G.C van Thiel, J.F van Pelt, & Yap SH. 2000. Equally Poten Inhibitor of Cholesterol Synthesis in Human Hepatocytes have Distinguishable Effects on Different Cytochrome P450 Enzymes. Biophram Drug Dispos. 21: 353-64.
European Society of Cardiology (ESC). 2010. Guidelines For The Management Of Atrial Fibrillation. European Heart Journal. 31: 2269-2429.
Jenssen. 2011. Highlights of Prescribing Information Xarelto® (Rivaroxaban). Bayer Healthcare. Germany.
Joenoes N.Z. 2006. Ars Prescribendi Resep Yang Rasional. Airlangga University Press.,Surabaya.
Kee, J.L. & E.R. Hayes. 1996. Farmakologi Pendekatan Proses Keperawatan. Penerbit Buku ECG, Jakarta.
Kubitza D., M. Becka, W. Mueck & M. Zuehlsdorf. 2006. Rivaroxaban(BAY 59-7939) – An Oral, Direct Factor Xa Inhibitor – Has No Clinically Relevant Interaction With Naproxen. British Journal of Clinical Pharmacology. 63: 469-476.
Neal. M.J. 2006. At a Glance Farmakologi Medis Edisi Kelima. Erlangga. Jakarta.
Nursalim A., & E. Setiabudi. 2012. Efektifitas Antikoagulan Baru Dibandingkan dengan Warfarin dalam Mencegah Stroke pada Pasien Atrial Fibrialis. Indon Med Assoc. 62: 407-411.
Riyanto B.W. 2011. Rivaroxaban untuk Pencegahan Stroke Sekunder pada Pasien AF. CDK (Cermin Dunia Kedokteran) 187. 38: 464.
Weinz C., T. Schwarz, D. Kubitza, W. Mueck & D. Lang. 2009. Metabolism And Excretion Of Rivaroxaban, An Oral, Direct Faktor Xa Inhibitor, In Rats, Dogs And Humans. Drugs Metabolism and Disposition. 37: 1056-1064.
Willeit K., R. Pechlaner, G. Egger, S. Weger, M. Oberhollenzer, J. Willeit, & S. Kiechl. 2013. Carotid Atherosclerosis and Incident Atrial Fibrillation. American Heart Association.
Yansen I., & Y. Yuniadi. 2013. Tata Laksana Fibrialis Atrium: Kontrol Irama atau Laju Jantung. Cermin Dunia Kedokteran. 40: 171-175.
DOI: http://dx.doi.org/10.20527/jps.v2i1.5815
Article Metrics
Abstract view : 4808 timesPDF - 5391 times
Refbacks
- There are currently no refbacks.
Copyright (c) 2019 Jurnal Pharmascience
Jurnal Pharmascience Published by:
Program Studi Farmasi Universitas Lambung Mangkurat
Banjarbaru, Indonesia
Jurnal Pharmascience is indexed by:
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.