MANAGEMENT OF SEVERE XEROSTOMIA AND ORAL CANDIDIASIS IN PATIENT WITH VALVULAR HEART DISEASE: A CASE REPORT
Abstract
Background: Valvular heart disease is a heart valve disorder that needs complex multiple medications by administering certain drugs that cannot be replaced with other drugs because of different mechanisms of action. Beta-blockers and Angiotensin-Converting Enzyme inhibitors are drugs of choice for valvular heart disease, with diuretics and antipsychotics can cause xerostomia. Valvular heart disease patient who has a severe infection or sepsis needs long-term antibiotic treatment. Xerostomia and long-term antibiotic treatment are predisposing factors for oral candidiasis. Objective: to discuss oral candidiasis and severe xerostomia because of multiple medications in valvular heart disease patients. Case: A 58-year-old male was referred from Cardiology and Vascular Medicine Department with a chief complaint of sore tongue and pain at swallowing since 3 days ago with dry sensation of the mouth. Extraoral examination revealed dry and exfoliative lips, intraoral examination revealed fissured and lobulated tongue and white plaques could be scraped off leaving erythematous area oropharynx and tongue. The diagnoses were oropharyngeal candidiasis and severe xerostomia score of 8 according to the Chalacombe scale. Case Management: Patient was treated with nystatin, chlorine dioxide, 0.12 % chlorhexidine digluconate mouthwash, and vaseline album. Oral candidiasis was disappeared on the 22nd day of treatment. Conclusion: Xerostomia and oral candidiasis in patients with valvular heart disease require appropriate therapy, more intensive monitoring by considering the patient's general condition, and interprofessional team collaboration in the therapy of the main disease.
Keywords: Oral candidiasis, Valvular heart disease, Xerostomia
Full Text:
PDFReferences
Chevalier M, Sakarovitch C, Precheur I, Lamure J, Pouyssegur-Rougier V. Antiseptic mouthwashes could worsen xerostomia in patients taing polypharmacy. Acta Odontol Scand. 2015 May;73(4):267-73.
Barbe AG. Medication-Induced Xerostomia and Hyposalivation in the Elderly: Culprits, Complications, and Management. Drugs Aging. 2018 Oct;35(10):877-885.
Nadig SD, Ashwathappa DT, Manjunath M, Krishna S, Annaji AG, Shivaprakash PK. A relationship between salivary flow rates and Candida counts in patients with xerostomia. J Oral Maxillofac Pathol. 2017 May-Aug;21(2):316.
Iung B, Vahanian A. Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol [Internet]. 2011;8(3):162–72.
Eacts CS, Germany CH, Rosenhek R, France EL, Rodriguez D, Tornos P, et al. 2017 ESC / EACTS Guidelines for the management of valvular heart disease The Task Force for the Management of Valvular Heart Disease of the European Society of Cardiology ( ESC ) and the European. 2017. 2739–2791 p.
Balakumar P, Kavitha M, Nanditha S. Cardiovascular drugs-induced oral toxicities: A murky area to be revisited and illuminated. Pharmacol Res. 2015 Dec;102:81-9.
Feller L, Khammissa RA, Chandran R, Altini M, Lemmer J. Oral candidosis in relation to oral immunity. J Oral Pathol Med. 2014 Sep;43(8):563-9.
Bergmeier LA. Oral Mucosa in Health and Disease. Vol. 2, Medical Journal of Australia. Springer International Publishing; 2018: 881–881 p.
Williams D, Lewis M. Pathogenesis and treatment of oral candidosis. J Oral Microbiol. 2011;3:10.3402/jom.v3i0.5771.
Kohli S, Shinde CV. Candidiasis and Oral Cavity : A Review. Int J Res Rev. 2019;6(5):336–7.
Mason KL, Downward JRE, Mason KD, Falkowski NR, Eaton KA, Kao JY, et al. Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy. Infect Immun. 2012;80(10):3371–80.
Einhorn OM, Georgiou K, Tompa A. Salivary dysfunction caused by medication usage. Physiol Int. 2020;107:195–208.
Turner MD. Hyposalivation and Xerostomia: Etiology, Complications, and Medical Management. Dent Clin North Am. 2016 Apr;60(2):435-43.
Garcia-Cuesta C, Sarrion-Pérez MG, Bagán JV. Current treatment of oral candidiasis: A literature review. J Clin Exp Dent. 2014 Dec 1;6(5):e576-82.
Epstein JB, Beier Jensen S. Management of Hyposalivation and Xerostomia: Criteria for Treatment Strategies. Compend Contin Educ Dent. 2015 Sep;36(8):600-3.
Pakfetrat M, Nikoo MH, Malekmakan L, Tabande M, Roozbeh J, Reisjalali G, et al. Risk Factors for contrast-related acute kidney njury according to risk, injury, failure, loss, and end-stage criteria in patients with coronary interventions. Iran J Kidney Dis. 2010 Apr;4(2):116-22.
Rao PK, Chatra L, Shai P, M VK. Oral Candidiasis – A Review. J Indian Dent Assoc. 2013;(5):8–13.
Ellepola ANB, Joseph BK, Khan ZU. Cell surface hydrophobicity of oral Candida dubliniensis isolates following limited exposure to sub-therapeutic concentrations of chlorhexidine gluconate. Mycoses. 2013;56(1):82–8.
Fathilah AR, Himratul-Aznita WH, Fatheen AR, Suriani KR. The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida. J Dent. 2012 Jul;40(7):609-15. d
Yadav SR, Kini VV, Padhye A. Inhibition of Tongue Coat and Dental Plaque Formation by Stabilized Chlorine Dioxide Vs Chlorhexidine Mouthrinse : A Randomized , Triple Blinded Study. J Clin Diagnostic Res. 2015;69–74.
Baldino MEL, Medina-Silva R, Sumienski J, et al. Nystatin effect on chlorhexidine efficacy against Streptococcus mutans as planktonic cells and mixed biofilm with Candida albicans. Clinical Oral Investigations. 2021 Jun. DOI: 10.1007/s00784-021-04041-0.
Scheibler E, da Silva RM, Leite CE, Campos MM, Figueiredo MA, Salum FG, Cherubini K. Stability and efficacy of combined nystatin and chlorhexidine against suspensions and biofilms of Candida albicans. Arch Oral Biol. 2018 May;89:70-76.
Amalia T, Setiadhi R. Terapi Kandidiasis pada Anak dengan Lupus Eritematosus Sistemik disertai Ko-infeksi Tuberkulosis. J Kedokt Gigi Univ Padjadjaran. 2019;31(3):201–6.
Sung E, Hernawan I. Tatalaksana serostomia akibat penggunaan metformin: laporan kasus (Management of metformin-induced xerostomia: case report). MDJ (Makassar Dent Journal). 2018;7(1):14–20.
Nugraha AP, Ernawati DS, Harijanti K, Parmadiati AE. Psychological Induced Xerostomia and Hyposalivation: The Case Study in Indonesian Female Patient. J Int Dent Med Res 2019; 12(1): 216-219
Asmi Usman N, Hernawan I. Tata Laksana Xerostomia Oleh Karena Efek Penggunaan Amlodipine: Laporan Kasus. Insisiva Dent J Maj Kedokt Gigi Insisiva. 2017;6(2). https://doi.org/10.18196/di.6284
DOI: http://dx.doi.org/10.20527/dentino.v6i2.12008
DOI (PDF): http://dx.doi.org/10.20527/dentino.v6i2.12008.g7629
Article Metrics
Abstract view : 1038 timesPDF - 503 times
Refbacks
- There are currently no refbacks.
Contact Us:
Faculty of Dentistry
Lambung Mangkurat University
Jalan Veteran No. 128 B Banjarmasin, Indonesia
E-mail. [email protected]
Website. fkg.ulm.ac.id
This work is licensed under a Creative Commons Attribution 4.0 International License.