PENGARUH EKSTRAK SEREH (Cymbopogon citratus) TERHADAP PANJANG LUKA MUKOSA LABIAL MENCIT SECARA KLINIS

Melinda Hairi, Nurdiana Dewi, Husnul Khatimah

Abstract


ABSTRACT
 
 Background: Lemongrass is one of the most widely used plants for traditional medicine. Lemongrass has bioactive substances such as phenolic acid, flavonoid, and tannin which act as anti-inflammatory and antioxidant agent which could affect the wound healing process. Purpose: The aim of this study was to assess the effects of 25%, 50%, and 100% lemongrass extract on mice labial mucosa clinical wound length by measuring the wound length. Methods: This study was a true experimental with post test-only with control design. 30 mice were used in this study, which were divided into 5 groups, patent drug containing Aloe vera extract as positive control group, 100% lemongrass extract group, 50% lemongrass extract group, 25% lemongrass extract group, and aquadest as negative control group. Results: One-way ANOVA and Post-hoc LSD tests showed significant difference between Aloe vera extract group, 100% lemongrass extract group, and 50% lemongrass extract group with aquadest group. There was no significant difference between Aloe vera extract group, 100% lemongrass extract group, and 50% lemongrass extract group. There was also no significant difference between 25% lemongrass extract group with aquadest group. Conclusion: Based on the conducted study, it can be concluded that 100% and 50% lemongrass extract could accelerate wound healing process on mice labial mucosa by measuring length of the wound.
 
Keywords: lemongrass extract, wound healing, wound length, oral mucosa, mice
 
ABSTRAK
 
 Latar Belakang:Sereh adalah salah satu tanaman yang sering digunakan sebagai obat tradisional.  Sereh mengandung zat bioaktif seperti phenolic acid, flavonoid dan tanin yang berperan sebagai antiinflamasi dan antioksidan yang berpengaruh dalam proses penyembuhan luka.Tujuan:Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak sereh 25%, 50%, dan 100% terhadap panjang luka mukosa labial mencit secara klinis dengan mengukur panjang luka. Metode:Penelitian ini merupakan eksperimental murni dengan rancangan post test-only with control design. Penelitian ini menggunakan 30 ekor mencit yang dibagi menjadi 5 kelompok, yaitu kelompok kontrol positif yang menggunakan obat paten mengandung ekstrak Aloe vera, kelompok ekstrak sereh 100%,  kelompok ekstrak sereh 50%, kelompok ekstrak sereh 25%, dan kelompok kontrol negatif menggunakan akuades.Hasil:Hasil uji One-way ANOVA dan Post-hoc LSD menunjukkan perbedaan yang bermakna antara kelompok ekstrak Aloe vera, kelompok ekstrak sereh 100%, dan kelompok ekstrak sereh 50% dibandingkan dengan kelompok akuades. Tidak terdapat perbedaan yang signifikan antara kelompok ekstrak Aloe vera, kelompok ekstrak sereh 100%, dan kelompok ekstrak sereh 50% serta tidak terdapat perbedaan yang signifikan antara kelompok ekstrak sereh 25% dan kelompok akuades.Kesimpulan:Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa ekstrak sereh 100% dan 50% dapat mempercepat penyembuhan luka mukosa labial mencit dilihat dari panjang luka.
 
Kata-kata kunci:ekstrak sereh, penyembuhan luka, panjang luka, mukosa mulut, mencit

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DOI: http://dx.doi.org/10.20527/dentino.v1i2.574

DOI (PDF): http://dx.doi.org/10.20527/dentino.v1i2.574.g487

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