Korelasi antara Kadar Kolesterol Total dengan Jumlah Monosit pada Pasien Penyakit Jantung Koroner

Fransiska Anggriani Salim; Miftahul Arifin; Asnawati Asnawati

doi:10.20527/jbk.v12i1.361

Korelasi antara Kadar Kolesterol Total dengan Jumlah Monosit pada Pasien Penyakit Jantung Koroner

Fransiska Anggriani Salim, Miftahul Arifin, Asnawati Asnawati

Abstract

Abstract: Coronary heart disease (CHD) is one of three leading causes of death in the world. CHD is a disease resulting from narrowing or blockage of the arteries that supply blood to the heart muscle. Total cholesterol and monocytes play an important role in the process of atherosclerosis that causes CHD. This study aimed to analyze the correlation between total cholesterol levels and monocytes count in patients with CHD in RSUD Ulin Banjarmasin in August 2014 to May 2015. This study use observational analytic study with cross-sectional approach. 92 samples selected according to the inclusion criteria. The results showed the average of total cholesterol levels and monocytes count are 198.41 mg/dL and 0.58 thousand/uL. The analysis with Pearson correlation test and give a result r=0.033 and p=0.758. The conclusion is there is a very weak, not significant and positive correlation between total cholesterol levels and monocytes count in patients with CHD.

Keywords: total cholesterol, monocytes, coronary heart disease

Abstrak: Penyakit jantung koroner (PJK) merupakan satu dari tiga penyebab utama kematian di dunia. PJK adalah penyakit yang timbul akibat penyempitan atau penyumbatan arteri yang memasok aliran darah ke otot jantung. Kolesterol total dan monosit berperan penting dalam proses aterosklerosis yang menyebabkan PJK. Penelitian ini bertujuan untuk menganalisis korelasi antara kadar kolesterol total dengan jumlah monosit pada pasien penyakit jantung koroner di RSUD Ulin Banjarmasin periode Agustus 2014-Mei 2015. Penelitian ini adalah penelitian observasional analitik dengan pendekatan cross-sectional. 92 sampel dipilih sesuai kriteria inklusi. Hasil penelitian menunjukkan rata-rata kadar kolesterol total dan jumlah monosit sebesar 198,41 mg/dL dan 0,58 ribu/uL. Kemudian dilakukan análisis dengan uji korelasi Pearson dan didapatkan nilai r=0,033 dan p=0,758. Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat korelasi yang sangat lemah, tidak signifikan dan searah antara kadar kolesterol total dengan jumlah monosit pada pasien PJK.

Kata-kata kunci: kolesterol total, monosit, penyakit jantung koroner

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DOI: http://dx.doi.org/10.20527/jbk.v12i1.361