GINGIVAL DEPIGMENTATION HEALING: A COMPARATIVE STUDY BETWEEN LIQUID PLATELET-RICH FIBRIN AND NON-EUGENOL PERIODONTAL PACK

Rezmelia Sari, Suryono Suryono

Abstract


Background: The gingival depigmentation procedure can result in extensive open wounds, patient discomfort, and an increased risk of infection. Non-Eugenol Periodontal (NEP) pack protects wounds from mechanical trauma but does not promote healing. Liquid Platelet-rich Fibrin (PRF) regenerates tissues; however, its effectiveness following gingival depigmentation remains unknown. Purpose: This study aims to compare post-gingival depigmentation outcomes after application of liquid PRF and NEP. Methods: Clinical trials were conducted on five healthy subjects who met the inclusion and exclusion criteria. Gingival depigmentation was performed in the anterior region using a scalpel, followed by the application of NEP (left) and PRF (right). Healing Index (HI), pain perception by Visual Analog Scale (VAS), and Wound Healing Score (WHS) were measured on days 5 and 7 then statistically analyzed with a significance value of p<0.05. Results: The HI on day 5 of the liquid PRF group was higher than NEP (p<0.05), but the HI on day 7, VAS on days 5 and 7, and WHS on days 5 and 7 were not significantly different (p>0.05).  Conclusion: Liquid PRF exhibits faster wound healing than NEP, however, both provide similar levels of comfort and epithelialization.


Keywords


gingiva hyperpigmentation; periodontal pack; platelet-rich fibrin; wound healing

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References


Roshna T, Nandakumar K. Anterior esthetic gingival depigmentation and crown lengthening: report of a case. J Contemp Dent Pract. 2005; 6(3): 139–47.

Wagle, Shreeprasad V, Agrawal A, Sankhe R. Gingival depigmentation using scalpel. Biomedical and Biotechnology Research Journal (BBRJ). 2018; 2(3): 223–225.

Nisa VM, Meilawaty Z, Astuti P. The effect of cassava leaves extract (Manihot Esculenta) on gingival wound healing in rats. Scientific Articles of Student Research Results. 2013; 1–7.

Kadkhodazadeh M, Baghani Z, Torshabi M. In vitro comparison of biological effects of Coe-Pak and Reso-Pac periodontal dressings. J Oral Maxillofac Res. 2017; Mar; 8(1): e3.

Savitha AN, Christopher S, Bose S. ResoPacTM - a novel periodontal dressing in comparison with Coe-Pak: a clinical study. I J Pre Clin Dent Res. 2015; 2(5): 32–37.

Bansal M, Kumar A, Puri K, Khatri M, Gupta G, Vij H. Clinical and histologic evaluation of Platelet-rich Fibrin accelerated epithelization of gingival wound. J Cutan Aesthet Surg. 2016; 9(3): 196–200.

Landry RG, Turnbull RS, Howley T. Effectiveness of benzydamyne HCl in the treatment of periodontal post-surgical patients. Res Clin Forums. 1988; 10: 105–118.

Sterczała B, Chwiłkowska A, Szwedowicz, U, Kobielarz M, Chwiłkowski B, Dominiak M. Impact of APRF+ in combination with autogenous fibroblasts on release growth factors, collagen, and proliferation and migration of gingival fibroblasts: an in vitro study. Materials. 2022; 15(3): 796.

Al-Maawi S, Becker K, Schwarz F, Sader R, Ghanaati S. Efficacy of Platelet-rich Fibrin in promoting the healing of extraction sockets: a systematic review. Int. J. Implant Dent. 2021; 7: 117.

Goel A, Windsor LJ, Gregory RL, Blanchard SB, Hamada Y. Effects of Platelet-rich Fibrin on human gingival and periodontal ligament fibroblast proliferation from chronic periodontitis versus periodontally healthy subjects. Clin. Exp. Dent. Res. 2021; 7(4): 436–442.

Gulsever S, Uckan S. Enhanced palatal wound healing with Leucocyte- and Platelet-rich Fibrin after free gingival graft harvesting: A prospective randomized controlled clinical trial. J. Clin. Med. 2025; 14(3): 1029.

Kulkarni MR, Thomas BS, Varghese JM, Bhat GS. Platelet-rich Fibrin as an adjunct to palatal wound healing after harvesting a free gingival graft: a case series. J. Indian Soc. Periodonto. 2014; 18(3): 399–402.

Marini L, Rojas MA, Sahrmann P, Aghazada R, Pilloni A. Early wound healing score: a system to evaluate the early healing of periodontal soft tissue wounds. J Periodontal Implant Sci. 2018; 48 (5): 274–283.

Chakravarthi S. Platelet-rich Fibrin in the management of established dry socket. J Korean Assoc Oral Maxillofac Surg. 2017; 43(3): 160–165.

Miyamoto H, Nakamura T, Takashima H, Mizutani T, Morita M, Hirose MKM, et al. Investigation of the analgesic effect of Platelet-rich Fibrin on postoperative pain after mandibular impacted wisdom tooth extraction. J. Oral Maxillofac. Surg. Med. Pathol. 2020; 32(4): 237–240.

Budisidharta Y, Syaify A, Lastianny SP. The effects of Zinc Oxide, Non-Eugenol, and Cellulose as periodontal dressings on open wounds after periodontal surgery. Dent J. 2020; 53 (1): 45–49.

Shetty GP, Lakade CH, Mitra DK, Rodrigues SV. Clinical and histological evaluation of concentrated growth factor membrane bandage after gingival depigmentation: A case series. J Indian Soc Periodontol. 2022; 26(5): 501–506.

Idris MI, Burhan AS, Hajeer MY, Sultan K, Nawaya FR. Efficacy of the injectable platelet-rich fibrin (I-PRF) in gingival phenotype modification: a systematic review and meta-analysis of randomized controlled trials. BMC Oral Health. 2024; 24(1): 1331.




DOI: http://dx.doi.org/10.20527/dentino.v11i2.26170

DOI (PDF): http://dx.doi.org/10.20527/dentino.v11i2.26170.g12536

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