Pengaruh Ekstrak Bunga Kecombrang (Etlingera elatior) terhadap Kadar Gula Darah dan Kolesterol Tikus Putih (Rattus novergicus) yang Diinduksi Aloksan

Irma Sinthia Simanjuntak; Erlintan sinaga; Melva silitonga

doi:10.20527/wb.v17i1.23683

Pengaruh Ekstrak Bunga Kecombrang (Etlingera elatior) terhadap Kadar Gula Darah dan Kolesterol Tikus Putih (Rattus novergicus) yang Diinduksi Aloksan

Irma Sinthia Simanjuntak, Erlintan sinaga, Melva silitonga

Abstract

This study aimed to investigate the effect of torch ginger (Etlingera elatior) extract on blood glucose and cholesterol levels in alloxan-induced white rats (Rattus novergicus). The research method used a completely randomized design (CRD) with 25 male rats in five treatment groups. All groups were induced with a single dose of alloxan (120 mg/kgBW). After three days, treatments were administered except for Group I. The groups consisted of: Group I (K0), normal control; Group II (K1), glibenclamide; Group III (P1), IV (P2), and V (P3), which received E. elatior extract at doses of 100, 200, and 400 mg/kgBW, respectively, for 14 days. Blood glucose and cholesterol levels were measured using a glucometer, and data were analyzed using One-Way ANOVA followed by DMRT. The results showed that E. elatior extract significantly reduced blood glucose and cholesterol levels, with the highest effect at 400 mg/kgBW. These findings indicate that Etlingera elatior extract exerts dose-dependent antihyperglycemic and antihypercholesterolemic effects, suggesting its potential as a candidate for herbal therapy.

Keywords

Etlingera elatior, Alloxan, Glibenclamide, Blood Glucose Level, Cholesterol Level

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DOI: http://dx.doi.org/10.20527/wb.v17i1.23683